Using genetics to understand eye development in frog and mouse
We have been working on eye development for over two decades and have expertise in genetic and molecular interactions. We have an understanding of the molecules required to make functional retinal neurons using the frog model. Will you help us figure out how mammalian retinal neurons form?
Our lab believes that we are all in this together. We are part of the Center for Vision Research, which meets weekly to discuss someone's latest unpublished findings. It gives our trainees the opportunity to practice scientific communication. We revel in our shared and individual accomplishments. We welcome collaboration and openness among our colleagues to answer fundamental questions in retinal cell biology. Please contact us if you would like to discuss how our research can work better together.
We use standard molecular and cellular mechanism tools to answer scientific questions about how pluripotent cells of the embryo develop into the complex neural tissue of the eye -- the retina. Our findings have been published in classic developmental biology textbooks & our basic-biological discoveries have paved the way for cell-based therapies for blindness.
Only two transcription factors, Pax6 and Tbx3, work together to form an eye from pluripotent frog cells. Learn more here.
The Viczian/Zuber labs used CRISPR/Cas9 to discover the regulatory region of one of the Eye-Field Transcription Factors (EFTFs). Learn more here.
We have discovered that Tbx3 does more than just regulate neuron formation. It also affects retinal vascular formation. Learn more here.
Please email us if you are interested in joining our efforts.
Current Positions: hiring a technician and graduate student.